GENERAL RESEARCH INTERESTS
Solid-state NMR spectroscopy, oxygen-17 and oxygen-18 isotopic labeling, mechanochemistry, biomaterials, nanomaterials, molecular materials, quadrupolar nuclei, structure and reactivity of interfaces, in-situ techniques for ball-milling, combined experimental-computational approaches in NMR, isotope effects.
The objective of the MISOTOP project is to develop a better understanding of the structure and properties of a variety of functional (nano)materials, thanks to advanced spectroscopic analyses involving the stable isotopes of oxygen (especially oxygen-17 NMR). Investigations are performed along 3 main directions :
- The implementation of new 17O and 18O isotopic labeling protocols using mechanochemistry
- Advanced NMR studies on 17O-enriched compounds
- The study of oxygen bonding environments at interfaces
More details on these studies can be found below and in the associated publications.
1. Oxygen-17 and oxygen-18 isotopic labeling using mechanochemistry
Because of the very low natural abundance of oxygen-17 (0.037%) and oxygen-18 (0.20 %), isotopic labeling is often needed for performing high-resolution spectroscopic studies of molecules and materials. However, up until recently, most oxygen-enrichment schemes were simply unattractive to a broad research community, because they were costly (due to the use of excessive quantities of enriched precursors) and/or experimentally constraining (due to the long reaction times or harsh synthetic conditions). This implied that spectroscopic techniques such as oxygen-17 NMR were only used by a small number of research groups.
In 2017, we demonstrated for the first time that protocols based on ball-milling can be used for the 17O-labeling of organic and inorganic compounds in a cost-efficient and user-friendly way. The reactions are all performed in a few hours under ambient conditions, and using very small quantities of 17O (or 18O) enriched water. Since then, we have been expanding the families of compounds which can be labeled by mechanochemistry, showing that it is applicable to oxides (SiO2, Al2O3, TiO2, ZrO2…), hydroxides (Ca(OH)2, Mg(OH)2…), carboxylic ligands (terephtalic acid, trimesic acid…), boronic acids, and small molecules of biological or pharmaceutical interest (ibuprofen…). Moreover, we have started to work on the scale-up of some of these reactions, so that the 17O (or 18O) enriched species can then be used as precursors in standard synthetic protocols of molecules and materials, and thereby help answer the needs of a wide community of chemists.
2. Advanced NMR studies on 17O-enriched compounds
Oxygen-17 spectroscopy is a highly attractive probe in solid state NMR, due to the wide range of variation of chemical shift (δiso > 1000 ppm) and quadrupolar parameters of 17O (|CQ| > 15 MHz). Nevertheless, its development has been slowed down by various factors, including the limited availability of enriched species. Here, the access to a broader variety of 17O-enriched species offers a whole new range of opportunities not only for elucidating the structure of complex molecular and materials systems, but also for performing new developments in the field of 17O solid state NMR. Our overall goal here is to develop a better understanding of the link between 17O NMR parameters and the local structure and dynamics around the oxygen, depending on the type of chemical bond it is involved in (covalent, coordination, hydrogen bond…).
In this context, we have been working along several directions, which include (i) performing higher resolution analyses at ultra-high fields (20 to 35.2T) to help finely resolve different oxygen sites, (ii) studying the structure and dynamics of various oxygen bonding environments through variable temperature analyses and computational modeling (including ab initio calculations of NMR parameters and molecular dynamics simulations), and (iii) using dynamic nuclear polarization (DNP) techniques for better resolving some of the 17O-sites enriched in ball-milling. Some of these investigations are performed on the instruments available in large scale facilities (IR-RMN THC network in France, UK high field NMR facility in Warwick, MagLab in Tallahassee), and in close collaboration with researchers from these laboratories.
3. Elucidation of interfacial bonding environments
Interfacial bonds are instrinsically difficult to characterize using techniques like NMR, notably because of the small number of interfacial atoms (in comparison to the bulk). However, a deep understanding of the structure and reactivity of interfaces is important to fully rationalize the properties of functional (nano)materials. Here, using molecules or materials enriched in oxygen-17 by ball milling, our goal is to perform high-resolution 17O NMR analyses to help identify the oxygen bonding environments at the surface or interface of (nano)materials. Our focus is set on studying (i) interfaces such as those which form during ball milling reactions (to help elucidate reaction mechanisms in mechanochemistry), (ii) organic-inorganic interfaces such as those present at the surface of nanoparticles or in hybrid biomaterials.